Title : Activation of p53 in MDM2-overexpressing cells through phosphorylation.

Pub. Date : 1999 Nov 2

PMID : 10544021






1 Functional Relationships(s)
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1 Although MDM2 protein was rapidly cleaved and degraded after anticancer drug treatment, cotreatment with caspase inhibitor Z-VAD blocked degradation, while wt p53 remained activated, suggesting MDM2 degradation not to be essential for the activation of p53. z-vad tumor protein p53 Homo sapiens