Title : Hyperglycemia enhances angiotensin II-induced janus-activated kinase/STAT signaling in vascular smooth muscle cells.

Pub. Date : 1999 Nov 5

PMID : 10542280






3 Functional Relationships(s)
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1 Furthermore, the tyrosine phosphorylation and activities of the SHP-1 and SHP-2 tyrosine phosphatases, enzymes that regulate Ang II-induced JAK2 tyrosine phosphorylation, are altered by HG. Tyrosine nuclear receptor subfamily 0 group B member 2 Homo sapiens
2 Furthermore, the tyrosine phosphorylation and activities of the SHP-1 and SHP-2 tyrosine phosphatases, enzymes that regulate Ang II-induced JAK2 tyrosine phosphorylation, are altered by HG. Tyrosine nuclear receptor subfamily 0 group B member 2 Homo sapiens
3 SHP-1, which is responsible for JAK2 tyrosine dephosphorylation in VSMC, is completely deactivated in HG, resulting in a prolonged duration of JAK2 phosphorylation under HG conditions. Tyrosine nuclear receptor subfamily 0 group B member 2 Homo sapiens