Title : Facilitation of the cellular uptake of a triplex-forming oligonucleotide by novel polyamine analogues: structure-activity relationships.

Pub. Date : 1999 Oct 5

PMID : 10529208






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Electrophoretic mobility shift assay revealed enhanced binding of TFO to a target duplex containing promoter region sequence of c-myc oncogene. tfo MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 Treatment of MCF-7 cells with the TFO complexed with 0.5 microM 3-4-3-4-3 suppressed c-myc mRNA level by 65%, as determined by Northern blot analysis. tfo MYC proto-oncogene, bHLH transcription factor Homo sapiens