Title : Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7.

Pub. Date : 1999 Jul-Aug

PMID : 10529008






3 Functional Relationships(s)
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1 Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7. Bile Acids and Salts UDP glucuronosyltransferase family 1 member A3 Homo sapiens
2 In this work, UDP-glucuronosyltransferases (UGTs), UGT1A3, 2B7(H268) and 2B7(Y268), stably expressed in human embryonic kidney cells (HK293) were used to assess glucuronidation activities with a variety of steroid hormone and bile acid substrates. Bile Acids and Salts UDP glucuronosyltransferase family 1 member A3 Homo sapiens
3 Expressed UGT1A3 catalyzed bile acid glucuronidation at high rates exclusively at the carboxyl moiety for all compounds tested. Bile Acids and Salts UDP glucuronosyltransferase family 1 member A3 Homo sapiens