Title : Decreasing oncoprotein 18/stathmin levels reduces microtubule catastrophes and increases microtubule polymer in vivo.

Pub. Date : 1999 Nov

PMID : 10523507






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Cells treated with Op18 antisense oligonucleotides for 4 days had (greater than or equal to)50% reduced levels of Op18 with no change in the soluble tubulin level. Oligonucleotides stathmin 1 Homo sapiens
2 Cells treated with Op18 antisense oligonucleotides for 4 days had (greater than or equal to)50% reduced levels of Op18 with no change in the soluble tubulin level. Oligonucleotides stathmin 1 Homo sapiens
3 Measurement of MT polymer level in untreated, antisense or nonsense oligonucleotide treated cells demonstrated that reduced Op18 levels resulted in a 2.5-fold increase in microtubule polymer. Oligonucleotides stathmin 1 Homo sapiens
4 The other parameters of dynamic instability were unchanged after reducing Op18 with antisense oligonucleotides. Oligonucleotides stathmin 1 Homo sapiens