Pub. Date : 1999 Oct
PMID : 10523334
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ang II (100 nmol/L for 120 minutes) caused formation of sis-inducing factor (SIF) complexes and tyrosine phosphorylation of STAT proteins in neonatal rat ventricular myocytes. | Tyrosine | signal transducer and activator of transcription 3 | Rattus norvegicus |
| 2 | In contrast, GP antagonist-2A, a peptide that selectively inhibits activation of G(q) proteins, completely abolished Ang II-stimulated SIF induction and STAT3 tyrosine phosphorylation. | Tyrosine | signal transducer and activator of transcription 3 | Rattus norvegicus |
| 3 | Pretreatment of cardiac myocytes with U73122, an inhibitor of phosphatidylinositol-specific phospholipase C (PLC) activity, decreased Ang II-stimulated SIF induction and STAT3 tyrosine phosphorylation in a dose-dependent manner. | Tyrosine | signal transducer and activator of transcription 3 | Rattus norvegicus |
| 4 | From these data, we conclude that Ang II-stimulated SIF induction and STAT3 tyrosine phosphorylation is mediated by PTX-insensitive G proteins through a G(q)-PLC-PKC-mediated pathway in neonatal rat ventricular myocytes. | Tyrosine | signal transducer and activator of transcription 3 | Rattus norvegicus |