Title : Synthesis of a disialylated hexasaccharide of type VIII group B Streptococcus capsular polysaccharide.

Pub. Date : 1999 Jun 30

PMID : 10520252






3 Functional Relationships(s)
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Compound Name
Protein Name
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1 This hexasaccharide represents a portion of the serotype-specific capsular polysaccharide of Type VIII that has the tetrasaccharide repeat unit [beta-L-Rhap-(1-->4)-beta-D-Glcp-(1-->4)-[alpha-Neu5Ac-(2--> 3)]-beta-D- Galp-(1-->4)]n. A tetrasaccharide corresponding to this repeat unit has been synthesized by us [E. Eichler, H.J. beta-l-rhap galanin like peptide Homo sapiens
2 This objective requires a glycosylation of the unreactive OH-4 of the beta-L-Rhap, which was accomplished by coupling a D-Galp glycosyl trichloroacetimidate donor with a beta-L-Rhap-(1-->4)-D-Glcp acceptor. beta-l-rhap galanin like peptide Homo sapiens
3 This objective requires a glycosylation of the unreactive OH-4 of the beta-L-Rhap, which was accomplished by coupling a D-Galp glycosyl trichloroacetimidate donor with a beta-L-Rhap-(1-->4)-D-Glcp acceptor. beta-l-rhap galanin like peptide Homo sapiens