Title : Immunosuppressive activity of glycosphingolipids. Influence of serum factors on ganglioside inhibition of IL-4-dependent cell proliferation.

Pub. Date : 1999

PMID : 10512048






5 Functional Relationships(s)
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1 Influence of serum factors on ganglioside inhibition of IL-4-dependent cell proliferation. Gangliosides interleukin 4 Homo sapiens
2 Gangliosides have been shown to inhibit proliferation of the interleukin-4 (IL-4) responsive cell line CT.4R. Gangliosides interleukin 4 Homo sapiens
3 Gangliosides have been shown to inhibit proliferation of the interleukin-4 (IL-4) responsive cell line CT.4R. Gangliosides interleukin 4 Homo sapiens
4 Dissociation constants of the IL-4-ganglioside complexes have been determined; lactosylceramide does not interact with rIL-4. Gangliosides interleukin 4 Homo sapiens
5 The K(d) values for the lymphokine complexes with gangliosides support the conclusion based on the kinetic analysis that IL-4 has a higher affinity for GM3 (K(d) = 5 nM) than for GM1 (K(d) = 0.28 microM). Gangliosides interleukin 4 Homo sapiens