Title : Regulation of G protein activation and effector modulation by fusion proteins between the human 5-hydroxytryptamine(1A) receptor and the alpha subunit of G(i1): differences in receptor-constitutive activity imparted by single amino acid substitutions in G(i1)alpha.

Pub. Date : 1999 Oct

PMID : 10496950






4 Functional Relationships(s)
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Protein Name
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1 Spiperone functioned as an inverse agonist in membranes expressing the 5-HT(1A) receptor wild-type G(i1)alpha fusion protein and in those expressing 5-HT(1A) receptor (Ile(351))G(i1)alpha but not the 5-HT(1A) receptor (Gly(351))G(i1)alpha fusion protein. Spiperone 5-hydroxytryptamine receptor 1A Homo sapiens
2 Spiperone functioned as an inverse agonist in membranes expressing the 5-HT(1A) receptor wild-type G(i1)alpha fusion protein and in those expressing 5-HT(1A) receptor (Ile(351))G(i1)alpha but not the 5-HT(1A) receptor (Gly(351))G(i1)alpha fusion protein. Spiperone 5-hydroxytryptamine receptor 1A Homo sapiens
3 Spiperone functioned as an inverse agonist in membranes expressing the 5-HT(1A) receptor wild-type G(i1)alpha fusion protein and in those expressing 5-HT(1A) receptor (Ile(351))G(i1)alpha but not the 5-HT(1A) receptor (Gly(351))G(i1)alpha fusion protein. Spiperone 5-hydroxytryptamine receptor 1A Homo sapiens
4 The effect of spiperone at the 5-HT(1A) receptor wild-type G(i1)alpha construct but not the 5-HT(1A) receptor (Ile(351))G(i1)alpha construct was blocked by pertussis toxin treatment. Spiperone 5-hydroxytryptamine receptor 1A Homo sapiens