Pub. Date : 1999 Jul
PMID : 10491778
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Influence of GSTM1 genotypes on anti-BPDE-DNA adduct levels in mononuclear white blood cells of humans exposed to PAH. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | phenylalanine hydroxylase | Homo sapiens |
| 2 | In coke-oven workers, chimney sweeps, and aluminum workers, respectively, the multiplicative effect of the null genotype with occupational PAH exposure gives risks of 162 (= 27.2 x 5.94), 10 (= 1.70 x 5.94), and 3 (= 0.50 x 5.94) times higher probability (risk) of high BPDE-DNA adduct formation than that of non-exposed subjects with the active GSTM1 genotype. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | phenylalanine hydroxylase | Homo sapiens |
| 3 | CONCLUSION: Our results indicate a greater risk of anti-BPDE-DNA adduct formation resulting from occupational high-level PAH-exposure in GSTM1 null (GSTM1 *0/*0) workers. | 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide | phenylalanine hydroxylase | Homo sapiens |