Title : Identification of wortmannin-sensitive targets in 3T3-L1 adipocytes. DissociationoOf insulin-stimulated glucose uptake and glut4 translocation.

Pub. Date : 1999 Aug 27

PMID : 10455135






2 Functional Relationships(s)
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1 This finding was confirmed by the demonstration that the PI3-kinase antagonist wortmannin inhibits GLUT4 and insulin-responsive aminopeptidase translocation with a dose response identical to that required to inhibit another class I PI3-kinase-dependent event, activation of pp70 S6-kinase. Wortmannin solute carrier family 2 member 4 Homo sapiens
2 Subsequent removal of wortmannin from the media shifted this dose-response curve to one resembling that for GLUT4 translocation and pp70 S6-kinase. Wortmannin solute carrier family 2 member 4 Homo sapiens