Title : Structure-based design of an RNA-binding zinc finger.

Pub. Date : 1999 Aug 17

PMID : 10449725






1 Functional Relationships(s)
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1 An arginine-rich alpha-helix from HIV-1 Rev was engineered into the zinc finger framework, and the designed fingers were shown to bind specifically to the RRE with high affinity and in a zinc-dependent manner, and display cobalt absorption and CD spectra characteristic of properly folded fingers. Arginine Rev Human immunodeficiency virus 1