Title : Modulation of fluorouracil antitumor activity by folic acid in a murine model system.

Pub. Date : 1999 Sep 1

PMID : 10449194






1 Functional Relationships(s)
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1 The biochemical basis for modulation of fluorouracil (FU) activity by leucovorin is elevation of the metabolite methylenetetrahydrofolate, which stabilizes the inhibitory ternary complex formed between thymidylate synthase and the active metabolite of FU, 5-fluorodeoxyuridylate. 5,10-methylenetetrahydrofolic acid thymidylate synthase Mus musculus