Title : DNA damage increases sensitivity to vinca alkaloids and decreases sensitivity to taxanes through p53-dependent repression of microtubule-associated protein 4.

Pub. Date : 1999 Aug 1

PMID : 10446979






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Increased expression of MAP4, which occurs when p53 is transcriptionally inactive, increases microtubule polymerization, paclitaxel binding, and sensitivity to paclitaxel, a drug that stabilizes polymerized microtubules. Paclitaxel tumor protein p53 Homo sapiens