Pub. Date : 1999 Sep 9
PMID : 10446454
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Apoptosis-promoting gene (bax) transfer potentiates sensitivity of squamous cell carcinoma to cisplatin in vitro and in vivo. | Cisplatin | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 2 | To investigate the role of bax gene expression in modulating cisplatin (CDDP)-induced apoptosis in vitro, an established CDDP-resistant human head and neck SCC (IMC-3 cell line) was transfected with bax gene-bearing mammalian expression vector. | Cisplatin | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 3 | Overexpression of the bax gene in CDDP-resistant IMC-3 cells elevated the CDDP susceptibility of tumor cells to a level similar to that of the parental IMC-3 cells. | Cisplatin | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 4 | Overexpression of the bax gene in CDDP-resistant IMC-3 cells elevated the CDDP susceptibility of tumor cells to a level similar to that of the parental IMC-3 cells. | Cisplatin | BCL2 associated X, apoptosis regulator | Homo sapiens |