Title : Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family.

Pub. Date : 1999 Aug 13

PMID : 10438522






1 Functional Relationships(s)
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1 We have expressed recombinant human ADAMTS11 in insect cells and shown that it cleaves aggrecan at the Glu(373)-Ala(374) site, with the cleavage pattern and inhibitor profile being indistinguishable from that observed with native aggrecanase. Glutamic Acid ADAM metallopeptidase with thrombospondin type 1 motif 5 Homo sapiens