Title : scFv multimers of the anti-neuraminidase antibody NC10: length of the linker between VH and VL domains dictates precisely the transition between diabodies and triabodies.

Pub. Date : 1999 Jul

PMID : 10436086






1 Functional Relationships(s)
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1 NC10 scFv molecules containing linkers of three and four residues showed a strong preference for dimer formation (diabodies), whereas a linker length of one or two glycine residues prevented the formation of diabodies and directed scFv association into trimers (triabodies). Glycine immunglobulin heavy chain variable region Homo sapiens