Title : Characterization of cytochrome P-450 2D1 activity in rat brain: high-affinity kinetics for dextromethorphan.

Pub. Date : 1999 Aug

PMID : 10421620






1 Functional Relationships(s)
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1 The enzyme activity was significantly (p <.01) and stereoselectively inhibited by CYP2D1 inhibitors quinine and quinidine (not by CYP2C or CYP3A inhibitors), and by anti-CYP2D6 peptide antiserum (not by anti-CYP2C, -CYP2B, or -CYP3A antibodies). Quinine cytochrome P450, family 2, subfamily d, polypeptide 1 Rattus norvegicus