Pub. Date : 1999 Jul 15
PMID : 10421546
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Paclitaxel sensitivity correlates with p53 status and DNA fragmentation, but not G2/M accumulation. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 2 | Although initial studies demonstrated that various DNA-damaging agents can induce p53, more recent studies have also shown p53 induction following nonDNA-damaging agents, including paclitaxel. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 3 | RESULTS: A 4-fold increase in paclitaxel sensitivity was observed among RKO cells deficient in p53 function compared with wild-type RKO cells (IC 50: 4 nM, 1 nM, 1nM for RKO, RKO.p53.13, RC 10.3, respectively). | Paclitaxel | tumor protein p53 | Homo sapiens |
| 4 | RESULTS: A 4-fold increase in paclitaxel sensitivity was observed among RKO cells deficient in p53 function compared with wild-type RKO cells (IC 50: 4 nM, 1 nM, 1nM for RKO, RKO.p53.13, RC 10.3, respectively). | Paclitaxel | tumor protein p53 | Homo sapiens |
| 5 | The increased cytotoxic effect in RKO cells with inactive p53 correlated with an increased propensity towards micronucleation and DNA fragmentation following paclitaxel treatment. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 6 | CONCLUSIONS: RKO cells lacking functional p53 demonstrate significantly enhanced sensitivity to paclitaxel compared with that of wild-type RKO cells. | Paclitaxel | tumor protein p53 | Homo sapiens |
| 7 | Although previous published reports of enhanced paclitaxel sensitivity in p53-deficient cells correlated this finding with increased G2/M arrest, we did not observe any significant correlation between paclitaxel-induced cell kill and the degree of mitotic arrest. | Paclitaxel | tumor protein p53 | Homo sapiens |