Pub. Date : 1999 Jun
PMID : 10411652
3 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | We show here that PtdIns, PtdIns4P, PtdIns3,4P2, PtdIns4,5P2 and PtdInsP3 enhance not only the C3-dependent ADP-ribosylation, but also the GDP/GTP exchange in the RhoA component of the prenylated RhoA/Rho-GDI complex. | Guanosine Diphosphate | Rho GDP dissociation inhibitor alpha | Homo sapiens | ||
| 2 | In contrast, in the nonprenylated RhoA/Rho-GDI complex, the levels of ADP-ribosylation and GDP/GTP exchange are of the same order as those measured on free RhoA and are not modified by phosphoinositides. | Guanosine Diphosphate | Rho GDP dissociation inhibitor alpha | Homo sapiens | ||
| 3 | We conclude that in the presence of phosphoinositides, the prenylated RhoA/Rho-GDI complex partially opens, which allows RhoA to exchange GDP for GTP. | Guanosine Diphosphate | Rho GDP dissociation inhibitor alpha | Homo sapiens | ||