Title : Molecular docking studies on interaction of diverse retinol structures with human alcohol dehydrogenases predict a broad role in retinoid ligand synthesis.

Pub. Date : 1999 Jul 13

PMID : 10407146






1 Functional Relationships(s)
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1 These findings suggest that ADH1B has a limited capacity to metabolize retinols, but that ADH4 is well suited to function in the metabolism of many diverse retinols and is predicted to participate in the synthesis of the active ligands all-trans-retinoic acid, 9-cis-retinoic acid, 3, 4-didehydroretinoic acid, 4-oxo-retinoic acid, and 4-hydroxy-retinoic acid. 4-oxoretinoic acid alcohol dehydrogenase 1B (class I), beta polypeptide Homo sapiens