Title : Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase.

Pub. Date : 1999 Aug

PMID : 10403731






2 Functional Relationships(s)
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1 METHODS: Trinitrobenzene sulphonic acid (TNBS) was instilled per rectum to induce a lethal colitis in iNOS deficient mice and in wild type controls. Trinitrobenzenesulfonic Acid nitric oxide synthase 2, inducible Mus musculus
2 Genetic ablation of iNOS gene conferred to mice a significant resistance to TNBS induced lethality and colonic damage, and notably reduced nitrotyrosine formation and concentrations of malondialdehyde; it did not, however, affect neutrophil infiltration and intestinal ICAM-1 expression in the injured tissue. Trinitrobenzenesulfonic Acid nitric oxide synthase 2, inducible Mus musculus