Title : Regulation of transforming growth factor-beta1 gene expression and cell proliferation in human hepatocellular carcinoma cells (PLC/PRF/5) by tamoxifen.

Pub. Date : 1999 Jul

PMID : 10402064






2 Functional Relationships(s)
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1 To further delineate whether tamoxifen may be of benefit in altering the course of HCC, we documented the effects of 4-hydroxytamoxifen and 17beta-estradiol on TGF-beta1 mRNA and protein levels and cell proliferation in a human HCC cell line. Estradiol transforming growth factor beta 1 Homo sapiens
2 4-Hydroxytamoxifen and 17beta-estradiol decreased TGF-beta1 mRNA and protein levels in a time- and dose-dependent manner. Estradiol transforming growth factor beta 1 Homo sapiens