Title : Methyltransferase inhibitor S-adenosyl-L-homocysteine sensitizes human breast carcinoma MCF7 cells and related TNF-resistant derivatives to TNF-mediated cytotoxicity via the ceramide-independent pathway.

Pub. Date : 1999 Jun

PMID : 10400831






2 Functional Relationships(s)
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1 Moreover, TNF-mediated cytotoxicity modulated by AdoHcy was blocked by the ICE-inhibiting peptide z-VAD-fmk, suggesting that an ICE-like protease is required for the methylation inhibition/TNF-inducible death pathway. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone tumor necrosis factor Homo sapiens
2 Moreover, TNF-mediated cytotoxicity modulated by AdoHcy was blocked by the ICE-inhibiting peptide z-VAD-fmk, suggesting that an ICE-like protease is required for the methylation inhibition/TNF-inducible death pathway. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone tumor necrosis factor Homo sapiens