Title : Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents.

Pub. Date : 1999 Jul

PMID : 10400422






4 Functional Relationships(s)
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1 Notably, clinical improvement was also correlated to ATRA/As2O3-induced rapid decrease of membrane procoagulant activity (PCA) and TF contents of APL blasts. Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
2 Consistent with the in vivo findings, the membrane PCA, TF antigen and its mRNA level within NB4 cells were rapidly down-regulated by 1 microM ATRA or As2O3, while 0.2 microg/ml DNR increased these TF parameters prior to its effect upon apoptosis induction. Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
3 Consistent with the in vivo findings, the membrane PCA, TF antigen and its mRNA level within NB4 cells were rapidly down-regulated by 1 microM ATRA or As2O3, while 0.2 microg/ml DNR increased these TF parameters prior to its effect upon apoptosis induction. Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens
4 On the other hand, in addition to its modulation on mRNA, As2O3 could also induce an accelerated TF protein turnover. Arsenic Trioxide coagulation factor III, tissue factor Homo sapiens