Title : K-ras mutations in 239PuO2 canine lung neoplasms.

Pub. Date : 1998 Oct 23

PMID : 10397446






1 Functional Relationships(s)
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1 The rate of K-ras mutations in plutonium-induced lung tumors described herein (8%) was greater than previously described in canine plutonium-induced lung tumors (0%), but was less than that which we have described in spontaneous canine lung cancer (16%), less than that reported for human spontaneous non-small cell lung cancer (13-36%) and less than that described in rats with spontaneous lung cancer (40%) or lung tumors following 239Pu inhalation exposure (46%). Plutonium-239 KRAS proto-oncogene, GTPase Canis lupus familiaris