Pub. Date : 1999 Jun 24
PMID : 10391249
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage. | Cisplatin | transformation related protein 73 | Mus musculus |
| 2 | Here we show that the amount of p73 protein in the cell is increased by cisplatin. | Cisplatin | transformation related protein 73 | Mus musculus |
| 3 | This induction of p73 is not seen in cells unable to carry out mismatch repair and in which the nuclear enzyme c-Abl tyrosine kinase is not activated by cisplatin. | Cisplatin | transformation related protein 73 | Mus musculus |
| 4 | The half-life of p73 is prolonged by cisplatin and by co-expression with c-Abl tyrosine kinase; the apoptosis-inducing function of p73 is also enhanced by the c-Abl kinase. | Cisplatin | transformation related protein 73 | Mus musculus |
| 5 | Our results indicate that c-Abl and p73 are components of a mismatch-repair-dependent apoptosis pathway which contributes to cisplatin-induced cytotoxicity. | Cisplatin | transformation related protein 73 | Mus musculus |