Title : Identification of SH2-bbeta as a potent cytoplasmic activator of the tyrosine kinase Janus kinase 2.

Pub. Date : 1999 Jun 22

PMID : 10377387






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SH2-Bbeta was previously identified as a JAK2-interacting protein that is tyrosyl phosphorylated in response to GH and other cytokines that activate JAK2. cyclo(tyrosyl-tyrosyl) growth hormone 1 Homo sapiens
2 More importantly, SH2-Bbeta enhanced GH-induced tyrosyl phosphorylation of endogenous JAK2 and ligand-induced tyrosyl phosphorylation of Stat5B by endogenous JAK2. cyclo(tyrosyl-tyrosyl) growth hormone 1 Homo sapiens
3 More importantly, SH2-Bbeta enhanced GH-induced tyrosyl phosphorylation of endogenous JAK2 and ligand-induced tyrosyl phosphorylation of Stat5B by endogenous JAK2. cyclo(tyrosyl-tyrosyl) growth hormone 1 Homo sapiens