Pub. Date : 1999 May
PMID : 10376804
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p42/p44 mitogen-activated protein kinase activation is involved in prostaglandin F2alpha-induced interleukin-6 synthesis in osteoblasts. | Dinoprost | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | Prostaglandin F2alpha (PGF2alpha) significantly induced p42/p44 mitogen-activated protein (MAP) kinase activity in osteoblast-like MC3T3-E1 cells. | Dinoprost | mitogen-activated protein kinase 3 | Mus musculus |
| 3 | Prostaglandin F2alpha (PGF2alpha) significantly induced p42/p44 mitogen-activated protein (MAP) kinase activity in osteoblast-like MC3T3-E1 cells. | Dinoprost | mitogen-activated protein kinase 3 | Mus musculus |
| 4 | PD98059, a selective inhibitor of MAP kinase kinase, inhibited PGF2alpha-induced interleukin-6 (IL-6) synthesis as well as PGF2alpha-induced p42/p44 MAP kinase activation. | Dinoprost | mitogen-activated protein kinase 3 | Mus musculus |
| 5 | Calphostin C, a highly potent and specific inhibitor of PKC, inhibited the PGF2alpha-induced p42/p44 MAP kinase activity. | Dinoprost | mitogen-activated protein kinase 3 | Mus musculus |
| 6 | These results strongly suggest that PKC-dependent p42/p44 MAP kinase activatioin is involved in PGF2alpha-induced IL-6 synthesis in osteoblasts. | Dinoprost | mitogen-activated protein kinase 3 | Mus musculus |