Pub. Date : 1999 Jun 25
PMID : 10373499
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The binding of cGMP to the noncatalytic sites on two isoforms of the phosphodiesterase (PDE) from mammalian rod outer segments has been characterized to evaluate their role in regulating PDE during phototransduction. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 2 | The binding of cGMP to the noncatalytic sites on two isoforms of the phosphodiesterase (PDE) from mammalian rod outer segments has been characterized to evaluate their role in regulating PDE during phototransduction. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 3 | Nonactivated, membrane-associated PDE (PDE-M, alpha beta gamma2) has one exchangeable site for cGMP binding; endogenous cGMP remains nonexchangeable at the second site. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 4 | Nonactivated, membrane-associated PDE (PDE-M, alpha beta gamma2) has one exchangeable site for cGMP binding; endogenous cGMP remains nonexchangeable at the second site. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 5 | Nonactivated, membrane-associated PDE (PDE-M, alpha beta gamma2) has one exchangeable site for cGMP binding; endogenous cGMP remains nonexchangeable at the second site. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 6 | Nonactivated, membrane-associated PDE (PDE-M, alpha beta gamma2) has one exchangeable site for cGMP binding; endogenous cGMP remains nonexchangeable at the second site. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 7 | Non-activated, soluble PDE (PDE-S, alpha beta gamma2 delta) can release and bind cGMP at both noncatalytic sites; the delta subunit is likely responsible for this difference in cGMP exchange rates. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 8 | Non-activated, soluble PDE (PDE-S, alpha beta gamma2 delta) can release and bind cGMP at both noncatalytic sites; the delta subunit is likely responsible for this difference in cGMP exchange rates. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 9 | Non-activated, soluble PDE (PDE-S, alpha beta gamma2 delta) can release and bind cGMP at both noncatalytic sites; the delta subunit is likely responsible for this difference in cGMP exchange rates. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 10 | Non-activated, soluble PDE (PDE-S, alpha beta gamma2 delta) can release and bind cGMP at both noncatalytic sites; the delta subunit is likely responsible for this difference in cGMP exchange rates. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 11 | Occupancy of the noncatalytic sites by cGMP may modulate the interaction of the gamma subunit with the alphabeta dimer and thereby regulate cytoplasmic cGMP concentration and the lifetime of activated PDE during visual transduction in photoreceptor cells. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |
| 12 | Occupancy of the noncatalytic sites by cGMP may modulate the interaction of the gamma subunit with the alphabeta dimer and thereby regulate cytoplasmic cGMP concentration and the lifetime of activated PDE during visual transduction in photoreceptor cells. | Cyclic GMP | aldehyde dehydrogenase 7 family member A1 | Homo sapiens |