Title : Bcl-2 and caspase inhibition cooperate to inhibit tumor necrosis factor-alpha-induced cell death in a Bcl-2 cleavage-independent fashion.

Pub. Date : 1999 Jun 25

PMID : 10373464






3 Functional Relationships(s)
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Protein Name
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1 Consistent with Bcl-2 cleavage being a caspase-mediated event, this cleavage is inhibitable by 50 microM CBZ-Val-Ala-Asp-fluoromethylketone (zVAD-fmk). benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone B cell leukemia/lymphoma 2 Mus musculus
2 Furthermore, Bcl-2 can cooperate with the caspase inhibitor zVAD-fmk in a dose-dependent manner to block TNFalpha-induced cell death. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone B cell leukemia/lymphoma 2 Mus musculus
3 Overexpression of Bcl-2 results in a 10-fold decrease in the amount of zVAD-fmk required to inhibit TNFalpha-induced apoptosis. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone B cell leukemia/lymphoma 2 Mus musculus