Title : Comparison of the effects on secretion in chromaffin and PC12 cells of Rab3 family members and mutants. Evidence that inhibitory effects are independent of direct interaction with Rabphilin3.

Pub. Date : 1999 Jun 18

PMID : 10364266






3 Functional Relationships(s)
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1 Many different types of experiments indicate that Rab3a is a negative regulator of exocytosis and that its GTP-bound form interacts with Rabphilin3, a possible effector. Guanosine Triphosphate RAB3A, member RAS oncogene family Rattus norvegicus
2 Binding constants for the interaction of the GTP-bound forms of Rab3a, Rab3b, Rab3c, and Rab3d with Rabphilin3 were comparable (Kd = 10-20 nM). Guanosine Triphosphate RAB3A, member RAS oncogene family Rattus norvegicus
3 Mutations in Rab3a were identified that strongly impaired the ability of the GTP-bound form to interact with Rabphilin3. Guanosine Triphosphate RAB3A, member RAS oncogene family Rattus norvegicus