Title : Regulation of Spi 2.1 and 2.2 gene expression after turpentine inflammation: discordant responses to IL-6.

Pub. Date : 1999 Jun

PMID : 10362600






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Induction of APR by turpentine injection includes activation of a STAT3 complex that can bind to a gamma-activated sequence (GAS) in the Spi 2.2 gene promoter, although the Spi 2.2 GAS site can bind STAT1 or STAT5 as well. Turpentine serine (or cysteine) peptidase inhibitor, clade A, member 3N Rattus norvegicus
2 This suggests the turpentine-induced increase of Spi 2.2 is mediated primarily by IL-6. Turpentine serine (or cysteine) peptidase inhibitor, clade A, member 3N Rattus norvegicus