Pub. Date : 1999 Jun
PMID : 10359601
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction. | lysophosphatidic acid | ras homolog family member A | Mus musculus |
| 2 | Using GST-ROK, we show that in N1E-115 neuronal cells LPA activates endogenous RhoA within 30 s, concomitant with growth cone collapse. | lysophosphatidic acid | ras homolog family member A | Mus musculus |
| 3 | LPA-induced RhoA activation is completely inhibited by tyrosine kinase inhibitors (tyrphostin 47 and genistein). | lysophosphatidic acid | ras homolog family member A | Mus musculus |
| 4 | Activated Galpha12 and Galpha13 subunits mimic LPA both in activating RhoA and in inducing RhoA-mediated cytoskeletal contraction, thereby preventing neurite outgrowth. | lysophosphatidic acid | ras homolog family member A | Mus musculus |
| 5 | Activated Galpha12 and Galpha13 subunits mimic LPA both in activating RhoA and in inducing RhoA-mediated cytoskeletal contraction, thereby preventing neurite outgrowth. | lysophosphatidic acid | ras homolog family member A | Mus musculus |
| 6 | We conclude that in neuronal cells, LPA activates RhoA to induce growth cone collapse and neurite retraction through a G12/13-initiated pathway that involves protein-tyrosine kinase activity. | lysophosphatidic acid | ras homolog family member A | Mus musculus |