Pub. Date : 1999 May 25
PMID : 10339565
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. | phosphatidylinositol 3,4,5-triphosphate | phosphatase and tensin homolog | Mus musculus |
| 2 | Inactivation of PTEN in ES cells and in embryonic fibroblasts resulted in elevated levels of phosphatidylinositol 3,4,5,-trisphosphate, a product of phosphatidylinositol 3 kinase. | phosphatidylinositol 3,4,5-triphosphate | phosphatase and tensin homolog | Mus musculus |
| 3 | Our studies suggest that PTEN regulates the phosphatidylinositol 3,4, 5,-trisphosphate and Akt signaling pathway and consequently modulates two critical cellular processes: cell cycle progression and cell survival. | phosphatidylinositol 3,4,5-triphosphate | phosphatase and tensin homolog | Mus musculus |