Title : Regulation of a novel pathway for cell death by lysosomal aspartic and cysteine proteinases.

Pub. Date : 1999

PMID : 10336074






2 Functional Relationships(s)
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1 In a culture of PC12 cells treated with acetyl-DEVD-cho, where caspase-3-like proteinases are not activated, CA074, a specific inhibitor of cathepsin B induced active death of the cells. N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline cathepsin B Rattus norvegicus
2 Cathepsin B antisense oligonucleotides showed a similar effect to CA074 on the induction of active cell death. N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline cathepsin B Rattus norvegicus