Title : Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1.

Pub. Date : 1999 Apr 8

PMID : 10327049






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Overexpression of a catalytically inactive form of SHP-1 prevents the PIR-B-mediated inhibition of tyrosine phosphorylation of Syk, Btk, and PLC-gamma2. Tyrosine nuclear receptor subfamily 0 group B member 2 Homo sapiens
2 Dephosphorylation of Syk and Btk mediated by SHP-1 leads to a decrease of their kinase activity, which in turn inhibits tyrosine phosphorylation of PLC-gamma2. Tyrosine nuclear receptor subfamily 0 group B member 2 Homo sapiens