Title : Reversible change in thiol redox status of the insulin receptor alpha-subunit in intact cells.

Pub. Date : 1999 May 4

PMID : 10231542






2 Functional Relationships(s)
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1 Short-term treatment of intact cells expressing large numbers of IR with GSH or NAC led to a rapid and reversible reduction of IR alpha-subunit disulfides, without affecting the receptor beta-subunit thiol reactivity. Disulfides X-linked Kx blood group Homo sapiens
2 Our results provide the first evidence that the IR alpha-subunit contains a select group of disulfides whose redox status can be rapidly altered by the reducing agents GSH and NAC. Disulfides X-linked Kx blood group Homo sapiens