Title : FcgammaRIIb modulation of surface immunoglobulin-induced Akt activation in murine B cells.

Pub. Date : 1999 May 7

PMID : 10224144






1 Functional Relationships(s)
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1 We hypothesized that the decreased Akt activity arises from the consumption of PtdIns 3,4,5-P3 by the inositol-5-phosphatase Src homology 2-containing inositol 5-phosphatase (SHIP), which has been shown by us to be tyrosine-phosphorylated and associated with FcgammaRIIb when the latter is co-ligated. phosphatidylinositol 3,4,5-triphosphate inositol polyphosphate-5-phosphatase D Mus musculus