Title : Site-selective modification of hyperreactive cysteines of ryanodine receptor complex by quinones.

Pub. Date : 1999 May

PMID : 10220560






2 Functional Relationships(s)
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1 Doxorubicin, 1,4-naphthoquinone (NQ), and 1, 4-benzoquinone (BQ) are found to selectively and dose-dependently interact with a class of hyperreactive sulfhydryl groups localized on ryanodine-sensitive Ca2+ channels [ryanodine receptor (RyR)], and its associated protein, triadin, of skeletal type channels. quinone ryanodine receptor 1 Homo sapiens
2 These results provide evidence that nanomolar quinone selectively and reversibly alters the redox state of hyperreactive sulfhydryls localized in the RyR/Ca2+ channel complex, resulting in enhanced channel activation. quinone ryanodine receptor 1 Homo sapiens