Title : Polyamine biosynthesis inhibitors alter protein-protein interactions involving estrogen receptor in MCF-7 breast cancer cells.

Pub. Date : 1999 Apr

PMID : 10194516






2 Functional Relationships(s)
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1 Estrogen receptor (ER) linked to glutathione-S-transferase (GST) was used to examine the effects of two polyamine biosynthesis inhibitors, difluoromethylornithine (DFMO) and CGP 48664. Eflornithine glutathione S-transferase kappa 1 Homo sapiens
2 When samples from the estradiol+DFMO treatment group were incubated with spermidine prior to GST-ER pull down assay, an increased association of several proteins with ER was detected. Eflornithine glutathione S-transferase kappa 1 Homo sapiens