Title : Interactions of surface-confined DNA with electroreduced mitomycin C comparison with acid-activated mitomycin C.

Pub. Date : 1999 Jan 1

PMID : 10190545






1 Functional Relationships(s)
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1 However, when the DNA-modified electrode was immersed in a MC solution and potentials corresponding to the quinone moiety reduction (- 0.3 V or more negative vs. SCE) were applied, an intrastrand bifunctional adduct between C-1 and C-10 of MC and two N-7 of a pair of adjacent guanines in ssDNA were formed at the electrode, reduced at - 0.49 V, i.e. 50 mV more negative than the monoadduct. quinone homeobox C10 Homo sapiens