Title : Magnitude of 5-HT1B and 5-HT1A receptor activation in guinea-pig and rat brain: evidence from sumatriptan dimer-mediated [35S]GTPgammaS binding responses.

Pub. Date : 1999 Apr 6

PMID : 10101238






1 Functional Relationships(s)
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1 The observed [35S]GTPgammaS binding responses in the substantia nigra are likely to be mediated by stimulation of the 5-HT1B receptor subtype, since they were antagonized by the 5-HT1B inverse agonist SB 224289 (10 microM), and not by the 5-HT2A/1D antagonist ketanserin (10 microM). Guanosine 5'-O-(3-Thiotriphosphate) 5-hydroxytryptamine receptor 2A Rattus norvegicus