Title : Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor.

Pub. Date : 1999 Mar 23

PMID : 10090736






1 Functional Relationships(s)
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Protein Name
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1 In meta-binding site I, the side chain of Glu209 (EL2) is within hydrogen-bonding distance (2.8 A) of the ribose O3", and Arg287 (EL3) coordinates both alpha- and beta-phosphates of the triphosphate chain, consistent with the insensitivity in potency of the 5"-monophosphate agonist, HT-AMP, to mutation of Arg287 to Lys. triphosphoric acid spectrin alpha, erythrocytic 1 Homo sapiens