Title : Turn scanning by site-directed mutagenesis: application to the protein folding problem using the intestinal fatty acid binding protein.

Pub. Date : 1998 Aug

PMID : 10082380






2 Functional Relationships(s)
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1 We have systematically mutated residues located in turns between beta-strands of the intestinal fatty acid binding protein (IFABP), and a glycine in a half turn, to valine and have examined the stability, refolding rate constants and ligand dissociation constants for each mutant protein. Fatty Acids fatty acid binding protein 2 Homo sapiens
2 IFABP is an almost all beta-sheet protein exhibiting a topology comprised of two five-stranded sheets surrounding a large cavity into which the fatty acid ligand binds. Fatty Acids fatty acid binding protein 2 Homo sapiens