Title : Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs.

Pub. Date : 1999 Mar 16

PMID : 10077674






1 Functional Relationships(s)
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1 Moreover, relative to COX-1 or COX-2, diclofenac-induced enzyme activity shows significantly reduced sensitivity to inhibition by diclofenac or other competitively acting nonsteroid antiinflammatory drugs (NSAIDs) and the enzyme activity is insensitive to aspirin. Diclofenac cytochrome c oxidase I, mitochondrial Mus musculus