Title : Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation.

Pub. Date : 1999 Mar 1

PMID : 10072524






1 Functional Relationships(s)
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1 Similar to conventional anergy (induction by signal 1 alone), the rapamycin-induced anergic cells show a decrease in mitogen-activated protein kinase activation, and these cells can be rescued by culture in IL-2. Sirolimus interleukin 2 Homo sapiens