Pub. Date : 1999 Mar 1
PMID : 10064605
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In human cells treated with the topoisomerase inhibitors camptothecin or etoposide (VP-16), we find that RPA2, the middle-sized subunit of RPA, becomes rapidly phosphorylated. | Camptothecin | replication protein A2 | Homo sapiens |
| 2 | RPA2 phosphorylation in response to camptothecin required ongoing DNA replication. | Camptothecin | replication protein A2 | Homo sapiens |
| 3 | Camptothecin itself partially inhibited DNA synthesis, and this inhibition followed the same kinetics as DNA-PK activation and RPA2 phosphorylation. | Camptothecin | replication protein A2 | Homo sapiens |
| 4 | DNA-PK activation and RPA2 phosphorylation were prevented by the cell-cycle checkpoint abrogator 7-hydroxystaurosporine (UCN-01), which markedly potentiates camptothecin cytotoxicity. | Camptothecin | replication protein A2 | Homo sapiens |