Pub. Date : 1999 Mar
PMID : 10051487
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A particular point mutation of the tumor suppressor gene p53, namely a G-->T transversion at the third base of codon 249, is frequently detected in primary hepatocellular carcinomas from patients living in areas where the levels of dietary exposure to aflatoxin B1 and the rates of infection with the hepatitis B virus are very high. | Aflatoxin B1 | tumor protein p53 | Homo sapiens |
| 2 | Thus, these results strongly support the view that the mutation at codon 249 of the p53 gene may serve as a fingerprint for aflatoxin B1-induced hepatocellular carcinomas, but is not, by itself, sufficient to immortalize human liver cells. | Aflatoxin B1 | tumor protein p53 | Homo sapiens |