Title : Oligonucleotide-europium complex conjugate designed to cleave the 5' cap structure of the ICAM-1 transcript potentiates antisense activity in cells.

Pub. Date : 1999 Mar 15

PMID : 10037819






3 Functional Relationships(s)
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1 Oligonucleotide-europium complex conjugate designed to cleave the 5" cap structure of the ICAM-1 transcript potentiates antisense activity in cells. Oligonucleotides intercellular adhesion molecule 1 Homo sapiens
2 This report shows that attachment of a Eu(THED)3+analog to the 3"-terminus of an antisense oligonucleotide, which targets the 5"-terminus of the intercellular adhesion molecule 1 mRNA, potentiates the inhibitory activity of the antisense oligonucleotide in cytokine-treatedendothelial cells. Oligonucleotides intercellular adhesion molecule 1 Homo sapiens
3 This report shows that attachment of a Eu(THED)3+analog to the 3"-terminus of an antisense oligonucleotide, which targets the 5"-terminus of the intercellular adhesion molecule 1 mRNA, potentiates the inhibitory activity of the antisense oligonucleotide in cytokine-treatedendothelial cells. Oligonucleotides intercellular adhesion molecule 1 Homo sapiens